With its theoretical bases powerfully found in evolutionary molecular and genetics population, comparative analyse the sequence have come to the necessary for reconstructing the evolutionary history concerning type and multi-gene families, appraise the list of expense of delivery of goods of molecular evolution, and inferring wide and nature of from selective armed forces which form evolution of gene and genomes. This requirement which is better recognized and have led to a very extend the horizon for application of statistical methods and computational. Since this method need usage of computer, requirement of the computer program is easy to used is good esteemed. This program have to contain the algorithm computational fast and worthwhile statistical methods, and they have to have a extensive user-interface so that they can be used by experimentalists work in forefront of sequence data generation and analysis up at invention of pattern romance as does exploration of base sequence attribute. Requirement double this push development from MEGA (Molecular Evolutionary Genetics Analysis) software in the early of 1990's.
From the beginning, goal from MEGA have been to make the available a the statistic wide and computational method to comparative analyse the sequence in a the environment is easy to operated. First version concerning MEGA, what is discharged in 1993, distributed to over 2000 scientist. MEGA2, released in 2001, is a complete rewrite from first version to take advantage of the manifold improvement in computing greatness of computer mean desktop, and availability of interface Microsoft Windows that graphical. User-friendliness and methodological advance concerning MEGA2 and the scope improved from evolutionary molecular analysis in scientific society led to a ten-fold improvement of amount userses from around the world. A survey of document research into the citing MEGA reveals that software used in different discipline, include to research into AIDS/HIV, virology, bacteriology and disease of public, plant the biology, biological conservation, systematic evolution, development, and genetika population.
Version MEGA the just discharged (3 and 4) extend ability from MEGA by adding the assembling features and straightness of sequence data, along with other progress. In version 3, acquisition of data sequence, effectively integrated with evolutionary analysis, make it many easier to do comparative analyse in a[n integrated computing environment. Version of 4 covering a unique facility to yield the text, is written in depict the legend format, to the purpose of to providing the natural Ianguage description concerning method and model use in analysis. Purpose of this facility to promote a better understanding of base assumption use in analysis, and result yield. New Other pattern is Maximum Composite Likelihood (MCL) method to appraise the evolutionary distance between all pairs sequence simultaneously, with and without accompanying the variation mount the rate between matter don't of a kind replacement pattern and location between lineage.
MEGA 4 presented FREE to be used in education and research.
MEGA
Saturday, August 29, 2009
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